L-Prolinamide → (2S)-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide

Participants

Reaction Steps

Following the procedures of Example 339, 2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulen-8-ol and L-prolinamide, were reacted and the crude product recrystallised from IMS to give 369 as a white solid (130 mg, 67%). LCMS: RT=2.48 min, [M+H]+=423. 1H NMR 400 MHz (DMSO-d6) δ: 9.06 (1 H, s), 7.80 (1 H, s), 7.35 (1 H, br), 6.94 (1 H, br), 5.96 (1 H, s), 5.90-5.88 (1 H, m), 4.50 (4 H, d, J=17.28 Hz), 4.32 (1 H, m), 3.61 (1 H, m), 3.45 (1 H, m)), 2.26 (2 H, s), 2.24-2.15 (1 H, m), 1.98-1.97 (3 H, m), 1.47 (6 H, dd, J=6.59, 3.27 Hz)

Provenance & Evidence