Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 86666431 | HCID 86666431 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178496191 | HCID 178496191 | — |
Reaction Steps
4-[6-amino-8-methoxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzoate (100 mg) is combined with sodium iodide (63 mg) and acetonitrile (10 mL), and then chlorotrimethylsilane (120 mL) is slowly added. The mixture is heated at 70° C. for 6 hours, cooled and filtered. The solid product is washed with water, then ether to yield 51 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08790655B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-1f70bc0eb5e84458bc93e6576b1ba2cd |
|---|
| Source note | uspto-grants-2014_07 |
|---|
