反应详情

To a solution of INT 5 (3.00 g, 16.4 mmol) and 3-bromo-4-methylaniline (3.06 g, 16.4 mmol) in MeOH (164 mL) was added decaborane (1.00 g, 8.2 mmol). The reaction mixture was stirred at room temperature overnight. More decaborane (0.50 g, 4.1 mmol) was added. The mixture was stirred at 60° C. for 2 hours. The mixture was concentrated. The residue was purified by chromatography on silica gel (heptane/EtOAc) to afford INT 8.

1. stirringThe mixture was stirred at 60° C. for 2 hours
2. concentrationThe mixture was concentrated
3. customThe residue was purified by chromatography on silica gel (heptane/EtOAc)
4. customto afford INT 8