HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-azetidinecarboxylic Acid → 1-{3-[(R)-1-(4-Chloro-3-methyl-phenyl)-propylamino]-4-fluoro-benzyl}-azetidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-azetidinecarboxylic Acid | HCID 93192 | — |
| Reactant | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| Reactant | (R)-1-(4-chloro-3-methyl-phenyl)-propylamine hydrochloride | HCID 57517333 | — |
| Product | 1-{3-[(R)-1-(4-Chloro-3-methyl-phenyl)-propylamino]-4-fluoro-benzyl}-azetidine-3-carboxylic acid | HCID 53340796 | — |
Reaction Steps
The title compound was prepared according to Scheme 3 following a procedure analogous to steps 3 to 6 of Example 21 using 3-bromo-4-fluoro-benzaldehyde in step 3, (R)-1-(4-chloro-3-methyl-phenyl)-propylamine hydrochloride in step 4 and azetidine-3-carboxylic acid in step 6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791100B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-84dd25580f7d41f68b40105c85b2475b |
| Source note | uspto-grants-2014_07 |