反应详情

温度

55 °C

To a stirred solution of Intermediate 107D (218 mg, 0.656 mmol) in MeOH (5 mL) was added 4.37 M NaOMe (0.750 mL, 3.28 mmol) in methanol solution. The reaction was heated to 55° C. for 5 h. The reaction mixture was concentrated and the residue was diluted with EtOAc. The organic layer was washed with 1 M HCl, dried over MgSO4, filtered and concentrated to yield the desired product (200 mg, 102%) as a light yellow solid. LCMS Anal. Calc'd for C17H20N2O3 300.15, found [M+H] 301.1.

1. concentrationThe reaction mixture was concentrated
2. additionthe residue was diluted with EtOAc
3. washThe organic layer was washed with 1 M HCl
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated