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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1629822Generated: October 27, 2026

Trifluoroacetic acid → HCID 178503700, compound

https://huagongshe.com/reaction/1629822

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-(2-Oxopyrrolidin-1-yl)benzoic acidHCID 773130—
Reactant(S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropylamineHCID 178503691—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178503700HCID 178503700—

Reaction Steps

Prepared analogously to Example 27 from 4-(pyrrolidin-2-on-1-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulphanyl-propylamine, PfTU and TEA in DMSO at ambient temperature and subsequent Boc cleaving with TFA analogously to Example 1g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791103B2
Source datasetuspto-grants-2014_07
ORD IDord-77b8690628f440c09fe0bdfaf8af214e
Source noteuspto-grants-2014_07