HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178454223 | HCID 178454223 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine | HCID 178511832 | — |
Reaction Steps
2.00 g (5.62 mmol) (1R)-N-Boc-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxy-ethylamine in 40 ml of ethyl acetate are combined with 8.0 ml 4-molar hydrochloric acid in dioxane while cooling in the ice bath and stirred for 16 hours at ambient temperature. The reaction mixture is evaporated down and the resulting precipitate is filtered off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791103B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e795b4ae27914ff6922569e5d13b67f3 |
| Source note | uspto-grants-2014_07 |