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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1629861Generated: October 31, 2026

Trifluoroacetic acid → (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine

https://huagongshe.com/reaction/1629861

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 178495124HCID 178495124—
SolventDichloromethaneHCID 6344—
Product(S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamineHCID 178495121—

Reaction Steps

Prepared analogously to Example 1g from (1S)-N-Boc-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxy-propylamine and TFA in dichloromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791103B2
Source datasetuspto-grants-2014_07
ORD IDord-d0c0e9484ed642e6a422af8c32d5da04
Source noteuspto-grants-2014_07