Ethyl 3-(2-benzyloxy-ethoxy)-propionate → Ethyl 3-(2-hydroxyethoxy)propanoate

HRID 1629875Notes

Reaction equation

HRID 1629875 reaction equation
C([O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

4

Reactant 1

HCID 66731906Ethyl 3-(2-benzyloxy-ethoxy)-propionate

Product 1

HCID 22394031Ethyl 3-(2-hydroxyethoxy)propanoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.73 g (14.8 mmol) ethyl 3-(2-benzyloxy-ethoxy)-propionate are hydrogenated together with 665 mg 10% palladium charcoal in 70 ml of ethanol for 44 minutes at ambient temperature under a hydrogen atmosphere at 3 bar. Then the mixture is suction filtered and the filtrate is evaporated down i. vac.

Workup

  1. filtrationfiltered
  2. customthe filtrate is evaporated down i

Sources & evidence

ORD record
ord-b290823003c54c97b3e6ce44645532ec
Source dataset
uspto-grants-2014_07
Patent number
US08791103B2

Reaction notes

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