HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ethyl 3-(2-chloro-ethoxy)-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Ethyl 3-(2-hydroxyethoxy)propanoate | HCID 22394031 | — |
| Product | Ethyl 3-(2-chloro-ethoxy)-propionate | HCID 85848654 | — |
Reaction Steps
2.26 g (13.9 mmol) ethyl 3-(2-hydroxy-ethoxy)-propionate are suspended in 5 ml (68.5 mmol) thionyl chloride and 20 μl (0.27 mmol) DMF are added. The reaction mixture is refluxed for 4 hours and then evaporated down i. vac. The product is further reacted without any more purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791103B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e8b80e37a07e42128ba246f172ef9c97 |
| Source note | uspto-grants-2014_07 |