HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(morpholin-3-on-4-yl)benzoic acid-chloride → N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-fluoro-4-(morpholin-3-on-4-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(morpholin-3-on-4-yl)benzoic acid-chloride | HCID 86069379 | — |
| Reactant | HCID 178495727 | HCID 178495727 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-fluoro-4-(morpholin-3-on-4-yl)-benzamide | HCID 178495744 | — |
Reaction Steps
Prepared analogously to Example 41d from 3-fluoro-4-(morpholin-3-on-4-yl)-benzoic acid-chloride and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine with TEA in THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791103B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-80ef8c2bd8ad492ab806cdaae0553781 |
| Source note | uspto-grants-2014_07 |