Potassium methoxide → HCID 56591860, compound

Participants

Reaction Conditions

Reaction Steps

A slurry of 50 mg (0.126 mmol) 2-(2-fluoro-phenyl)-4-(8-nitro-isoquinolin-5-yl)-[1,8]naphthyridine (synthesis see example 6) in 1 ml methanol was treated with 26.5 mg (3.0 mmol) potassium methylate. The mixture was stirred at 60° C. under nitrogen for 18 hours. The reaction mixture was cooled to room temperature. The solid was filtered off, washed with little methanol and dried under vacuum yielding 2-(2-fluoro-phenyl)-4-(8-methoxy-isoquinolin-5-yl)-[1,8]naphthyridine as colourless solid; HPLC/MS: 1.74 min, [M+H] 382.

Provenance & Evidence