Ethylene Glycol → HCID 56592118, compound

Participants

Reaction Conditions

Reaction Steps

A slurry of 198 mg (0.50 mmol) 2-(2-fluoro-phenyl)-4-(8-nitro-isoquinolin-5-yl)-[1,8]naphthyridine (synthesis see example 6) in 1 ml ethane-1,2-diol was treated with 326 mg (1.00 mmol) cesium carbonate. The resulting slurry was stirred at 80° C. for two days. The reaction mixture was cooled to room temperature and diluted with water. The resulting precipitate was filtered off, washed with water and chromatographed on a silica gel column with dichloromethane/methanol as eluent yielding 2-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-isoquinolin-8-yloxy}-ethanol as colourless crystals; HPLC/MS: 1.53 min, [M+H] 412.

Provenance & Evidence