Acetic Anhydride → HCID 56592379, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 37 mg (0.10 mmol) 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine in 0.5 ml acetic acid was treated with 20.4 mg (0.20 mmol) acetic acid anhydride and heated to 80° C. The reaction mixture was stirred at this temperature for 18 hours. The reaction mixture was cooled to room temperature and partitioned between 25% aqueous ammonia and dichloromethane. The organic phase was dried over sodium sulphate and evaporated. The residue was triturated with tert-butyl-methylether yielding N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide as brown crystals; HPLC/MS (A) 1.64 min, [M+H] 410.

Provenance & Evidence