4-(4-Chlorophenoxy)aniline → HCID 67010380, compound

HRID 1630048Notes

Reaction equation

HRID 1630048 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.C(OC([NH:23][C@@H:24]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:25](O)=[O:26])=O)(C)(C)C>>[NH2:23][C@@H:24]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:25]([NH:11][C:10]1[CH:12]=[CH:13][C:7]([O:6][C:5]2[CH:14]=[CH:15][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1)=[O:26]

Participants

3

Reactant 2

HCID 75784-(4-Chlorophenoxy)anilineHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

Product 1

HCID 67010380HCID 67010380, compoundYield 13%

Procedure

Proceeding as in Reference 5, but substituting 4-(4-chlorophenoxy)aniline and (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid, gave (S)-2-amino-N-(4-(4-chlorophenoxy)phenyl)-3-phenylpropanamide (45 mg, 13%).

Sources & evidence

ORD record
ord-366fad459ddc49749d7727af54523c40
Source dataset
uspto-grants-2014_07
Patent number
US08791102B2

Reaction notes

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