Benzenamine, 4-(4-fluorophenoxy)- → HCID 67009813, compound

HRID 1630050Notes

Reaction equation

HRID 1630050 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[C:16]([NH:19][CH2:20][CH2:21][CH2:22][C@H:23]([NH:27]C(OC(C)(C)C)=O)[C:24](O)=[O:25])(=[O:18])[CH3:17]>>[C:16]([NH:19][CH2:20][CH2:21][CH2:22][C@H:23]([NH2:27])[C:24]([NH:11][C:10]1[CH:12]=[CH:13][C:7]([O:6][C:5]2[CH:14]=[CH:15][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1)=[O:25])(=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 147633Benzenamine, 4-(4-fluorophenoxy)-HCID 54409807HCID 54409807, compound

Product 1

HCID 67009813HCID 67009813, compoundYield 56%

Procedure

Proceeding as in Reference 5, but substituting 4-(4-fluorophenoxy)aniline and (S)-5-acetamido-2-(tert-butoxycarbonylamino)pentanoic acid, gave (S)-5-acetamido-2-amino-N-(4-(4-fluorophenoxy)phenyl)pentanamide (200 mg, 56%).

Sources & evidence

ORD record
ord-7baff5109fae4bd88396b6e2ef9f633d
Source dataset
uspto-grants-2014_07
Patent number
US08791102B2

Reaction notes

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