HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| Reactant | Benzenamine, 4-(4-fluorophenoxy)- | HCID 147633 | — |
| Product | (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide | HCID 67009137 | 69% |
Reaction Steps
Proceeding as in Reference 5, but substituting 4-(4-fluorophenoxy)aniline and (S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoic acid, gave (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (443 mg, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791102B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1190d9bfb66d475d9c6e486bdaa3f6b2 |
| Source note | uspto-grants-2014_07 |