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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1630069Generated: November 1, 2026

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid → (2S,4R)-N-(4-(4-fluoro-3-methylphenoxy)phenyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/1630069

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acidHCID 2761972—
ReactantHCID 67009392HCID 67009392—
Product(2S,4R)-N-(4-(4-fluoro-3-methylphenoxy)phenyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxamideHCID 6700947273%

Reaction Steps

Proceeding as in Reference 6, but substituting 4-(4-fluoro-3-methylphenoxy)aniline and (2S,4R)-1-(tert-butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid, gave (2S,4R)—N-(4-(4-fluoro-3-methylphenoxy)phenyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxamide (282 mg, 73%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791102B2
Source datasetuspto-grants-2014_07
ORD IDord-8881d5ef1a414e7398f5a80be793d299
Source noteuspto-grants-2014_07