Ammonium formate → HCID 58118725, compound

Participants

Reaction Steps

A mixture of 5-(4-fluorophenoxy)-2-nitroaniline (410 mg, 1.65 mmol), ammonium formate (520 mg, 8.26 mmol), 10% palladium on carbon (123 mg, 0.116 mmol) and methanol (10 mL) was stirred at ambient temperature for 30 minutes. The mixture was filtered and filtrate was concentrated. Product was purified from the residue by silica gel column chromatography (eluted with a 2:3→1:2 of hexane/EtOAc) to give 4-(4-fluorophenoxy)benzene-1,2-diamine (370 mg, quant) as a brown oil.

Provenance & Evidence