2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride → (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide

Beteiligte Stoffe

Reaktionsschritte

Proceeding as in Example 1, but substituting (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide and 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride, gave Compound 149, (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide (45 mg, 66%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.26 (br s, 1H), 8.84-8.78 (d, 1H), 8.48 (s, 1H) 7.96 (s, 2H), 7.63-7.59 (d, 2H), 7.32-7.28 (m, 5H), 7.23-7.19 (t, 2H), 7.04-6.98 (m, 4H), 5.03 (s, 2H), 4.76-4.69 (m, 1H), 4.54 (s, 2H), 3.69-3.67 (d, 2H). MS (EI) for C26H24FN5O4. found 490.0 (MH+).

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