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HRID1630091

反应详情

EQUATION

反应方程式

HRID 1630091 的结构方程式

REACTANTS

反应物

2
结构：Cl.O=C(O)Cn1cncn1
HCID44887050

1H-1,2,4-Triazole-1-acetic acid, monohydrochloride

C4H6ClN3O2

结构：N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID86659466

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Cn1cncn1)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID70641275

未命名化合物

收率 20%

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting (S)-benzyl 4-amino-5-(4-(4-fluorophenoxy)phenylamino)-5-oxopentylcarbamate and 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride, gave Compound 165, (S)-benzyl 4-(2-(1H-1,2,4-triazol-1-yl)acetamido)-5-(4-(4-fluorophenoxy)phenylamino)-5-oxopentylcarbamate (90.1 mg, 20%). 1H-NMR (400 MHz, DMSO-D6): σ 10.19 (s, 1H), 8.69 (d, 1H), 8.48 (s, 1H), 7.96 (s, 1H), 7.60 (d, 2H), 7.39-7.29 (m, 5H), 7.21 (m, 2H), 7.04-6.96 (m, 4H), 5.00-4.97 (m, 4H), 4.46-4.39 (m, 1H), 3.04-2.99 (m, 2H), 1.75-1.39 (m, 4H). MS (EI) for C29H29FN6O5. found 560.9 (MH+).