2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride → (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1,2,4)-triazol-1-ylacetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide, gave Compound 146, (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide (106 mg, 82%). 1H-NMR (400 MHz, CDCl3): σ 8.69 (s, 1H), 8.41 (br s, 1H), 7.64 (d, 1H), 7.58 (d, 1H), 7.44 (d, 2H), 7.39-7.25 (m, 6H), 7.10-7.06 (m, 2H), 6.99-6.97 (m, 4), 5.03-4.99 (m, 1H), 4.76 (d, 1H), 4.65 (d, 1H), 4.25 (dd, 1H), 3.78 (dd, 1H). MS (EI) for C26H25N5O4. found 472.1 (MH+).

Provenance & Evidence