2-(2,4-Dioxoimidazolidin-1-yl)acetic acid hydrochloride → (S)-3-(benzyloxy)-2-(2-(2,4-dioxoimidazolidin-1-yl)acetamido)-N-(4-phenoxyphenyl)propanamide

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2,4-dioxoimidazolidin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide, gave Compound 201, (S)-3-(benzyloxy)-2-(2-(2,4-dioxoimidazolidin-1-yl)acetamido)-N-(4-phenoxyphenyl)propanamide (54.1 mg, 45%). 1H-NMR (400 MHz, DMSO-D6): σ 10.62 (d, 1H), 10.15 (d, 1H), 8.47-8.41 (m, 1H), 7.83 (d, 1H), 7.65-7.61 (m, 2H), 7.39-7.26 (m, 6H), 7.10 (t, 1H), 7.02-6.96 (m, 4H), 4.73-4.66 (m, 1H), 4.53 (s, 2H), 4.25-4.20 (m, 1H), 3.71-3.63 (m, 2H), 2.73-2.63 (m, 1H). MS (EI) for C27H26N4O6. found 503.1 (MH+).

Provenance & Evidence