(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → (S)-3-(benzyloxy)-2-(2-(3,5-dimethylisoxazol-4-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide

関与物質

反応手順

Proceeding as in Example 1, but substituting 2-(3,5-dimethylisoxazol-4-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 150, (S)-3-(benzyloxy)-2-(2-(3,5-dimethylisoxazol-4-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (48 mg, 72%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (br s, 1H), 8.52-8.50 (d, 1H), 7.63-7.60 (d, 2H), 7.33-7.27 (m, 5H), 7.23-7.19 (t, 2H), 7.03-6.98 (m, 4H), 4.73-4.68 (m, 1H), 4.53 (s, 2H), 3.70-3.63 (m, 1H), 3.31 (s, 2H), 2.28 (s, 3H), 2.11 (s, 3H). MS (EI) for C29H28FN3O5. found 518.0 (MH+).

情報源と証拠