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HRID1630095

反应详情

EQUATION

反应方程式

HRID 1630095 的结构方程式

REACTANTS

反应物

2
结构：N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID67009137

未命名化合物

结构：Cl.O=C(O)Cn1nnc2ccccc21
HCID67009250

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Cn1nnc2ccccc21)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID67009278

未命名化合物

收率 59%

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting 2-(1H-benzo[d][1,2,3]triazol-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 151, (S)-2-(2-(1H-benzo[d][1,2,3]triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (41 mg, 59%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.25 (br s, 1H), 9.04-9.02 (d, 1H), 8.05-8.03 (d, 1H), 7.78-7.76 (d, 1H), 7.64-7.60 (d, 2H), 7.53-7.49 (t, 1H), 7.41-7.38 (t, 1H), 7.33-7.28 (m, 5H), 7.23-7.19 (t, 2H), 7.05-6.98 (m, 4H), 5.59 (s, 1H), 4.77-4.72 (m, 1H), 4.56 (s, 1H), 3.73-3.72 (d, 2H). MS (EI) for C30H26FN5O4. found 540.0 (MH+).