反应详情

Proceeding as in Example 1, but substituting 2-morpholin-4-ylacetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 155, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-morpholinoacetamido)propanamide (23 mg, 17%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.20 (br s, 1H), 7.98-7.96 (d, 1H), 7.61-7.57 (d, 2H), 7.33-7.26 (m, 5H), 7.23-7.19 (t, 2H), 7.04-6.97 (m, 4H), 4.72-4.67 (m, 1H), 4.52 (s, 2H), 3.78-3.68 (m, 2H), 3.59-3.57 (t, 4H), 2.99 (s, 2H), 2.47-2.42 (m, 4H). MS (EI) for C28H30FN3O5. found 508.0 (MH+).