(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009520, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-piperazin-1-ylacetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 205, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(piperazin-1-yl)acetamido)propanamide (15 mg, 11%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.18 (br s, 1H), 7.97-7.95 (d, 1H), 7.61-7.57 (d, 2H), 7.33-7.27 (m, 5H), 7.23-7.19 (t, 2H), 7.04-6.97 (m, 4H), 4.71-4.69 (m, 1H), 4.52 (s, 2H), 3.78-3.67 (m, 2H), 2.96 (s, 2H), 2.77-2.75 (t, 4H), 2.42 (s, 4H), 1.91 (s, 1H). MS (EI) for C28H31FN4O4. found 507.0 (MH+).

Provenance & Evidence