53958-93-3 → HCID 67009865, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 3-(1H-imidazol-5-yl)propanoic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 207, (S)-2-(3-(1H-imidazol-5-yl)propanamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (18.4 mg, 5%). 1H-NMR (400 MHz, DMSO-D6): σ 10.19 (s, 1H), 8.29 (d, 1H), 7.60 (d, 2H), 7.46 (s, 1H), 7.29-7.16 (m, 6H), 7.01-6.94 (m, 4H), 6.73 (s, 1H), 4.70-4.64 (m, 1H), 4.50 (s, 2H), 2.73-2.67 (m, 2H), 2.48-2.43 (m, 4H). MS (EI) for C28H27FN4O4. found 503.2 (MH+).

Provenance & Evidence