HCID 46735248, compound → HCID 67009740, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(pyrazin-2-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 159, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyrazin-2-yl)acetamido)propanamide (66 mg, 46%). 1H-NMR (400 MHz, CDCl3): σ 8.63-8.44 (m, 4H), 7.40-7.19 (m, 9H), 7.05-6.92 (m, 3H), 4.74-4.70 (m, 1H), 4.66 (d, 1H), 4.55 (d, 1H), 4.10 (dd, 1H), 3.85 (s, 2H), 3.64 (dd, 1H). MS (EI) for C28H25FN4O4. found 501.2 (MH+).

Provenance & Evidence