2-(Morpholin-4-yl)acetic acid hydrochloride → (S)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-morpholinoacetamido)propanamide

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-morpholin-4-ylacetic acid hydrochloride and (S)-2-amino-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 210, (S)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-morpholinoacetamido)propanamide (60 mg, 55%). 1H-NMR (400 MHz, CDCl3): δ 8.45 (s, 1H), 8.00 (s, 1H), 7.37-7.25 (m, 5H), 7.10-6.90 (m, 7H), 4.79-4.73 (m, 1H), 4.63 (m, 2H), 4.00-3.80 (m, 6H), 3.20-3.10 (s, 2H), 2.60-2.45 (m, 4H). MS (EI) for C28H29F2N3O5 found 526 (MH+).

Provenance & Evidence