反应详情

Proceeding as in Example 1, but substituting 2-(1H-imidazol-4-yl)-2-methylpropanoic acid hydrochloride and (S)-2-amino-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 161, (S)-2-(2-(1H-imidazol-4-yl)-2-methylpropanamido)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (92.2 mg, 60%). 1H-NMR (400 MHz, CDCl3): δ 9.31 (s, 1H), 8.32 (br s, 1H), 7.49-7.45 (m, 3H), 7.38 (d, 1H), 7.22-7.18 (m, 2H), 7.02-6.88 (m, 7H), 6.83 (s, 1H), 4.72-4.68 (m, 1H), 4.51 (d, 1H), 4.44 (d, 1H), 4.04 (dd, 1H), 3.63 (dd, 1H), 1.56 (s, 3H), 1.55 (s, 3H). MS (EI) for C29H29F2N4O4 found 535 (MH+).