(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 45376362, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(5-fluoro-1H-indol-3-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 212, (S)-3-(benzyloxy)-2-(2-(5-fluoro-1H-indol-3-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (78 mg, 70%). 1H-NMR (400 MHz, DMSO-D6): σ 10.98 (s, 1H), 10.17 (s, 1H), 8.37 (d, 1H), 7.63-7.57 (m, 2H), 7.39-7.16 (m, 9H), 7.05-6.95 (m, 4H), 6.93-6.86 (m, 1H), 4.75-4.67 (m, 1H), 4.50 (s, 2H), 3.70-3.53 (m, 4H). MS (EI) for C32H27F2N3O4. found 555.9 (MH+).

Provenance & Evidence