(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 178432815, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2-methyl-1H-imidazol-4-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 162, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-methyl-1H-imidazol-4-yl)acetamido)propanamide (52 mg, 7%). 1H-NMR (400 MHz, DMSO-D6): σ 10.19 (s, 1H), 8.40-8.36 (m, 2H), 7.61 (d, 2H), 7.32-7.18 (m, 6H), 7.04-6.97 (m, 3H), 6.74 (br s, 1H), 4.69-4.64 (m, 1H), 4.52 (s, 2H), 3.67-3.54 (m, 4H), 2.20 (s, 3H). MS (EI) for C28H27FN4O4. found 503.2 (MH+).

Provenance & Evidence