(4-Phenylpiperazin-1-yl)acetic acid--hydrogen chloride (1/1) → HCID 67009523, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-phenylpiperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 225, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-phenylpiperazin-1-yl)acetamido)propanamide (13.4 mg, 28.7%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.23 (s, 1H), 8.02 (s, 1H), 7.60 (d, 2H), 7.28-7.29 (m, 4H), 7.19-7.26 (m, 5H), 6.99-7.04 (m, 4H), 6.92 (d, 2H), 6.78 (t, 1H), 4.71 (m, 1H), 4.52 (s, 2H), 3.76 (m, 2H), 3.13 (m, 4H), 3.07 (s, 2H), 2.63 (m, 4H). MS (EI) for C34H35FN4O4. found 583.6 (MH+).

Provenance & Evidence