(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009185, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(2-methoxyphenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 217, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)acetamido)propanamide (19 mg, 38.8%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.23 (1H), 5.02 (d, 1H), 7.61 (d, 2H), 7.25-4.30 (m, 4H), 7.20-7.23 (m, 3H), 4.00-7.04 (m, 3H), 6.85-6.98 (m, 5H), 4.71 (m, 1H), 4.53 (s. 2H), 3.80 (m, 1H), 3.77 (s, 3H), 3.72 (m, 1H), 3.05 (d, 2H), 2.99 (m, 4H), 2.62 (m, 4H). MS (EI) for C35H37FN4O5. found 613.6 (MH+).

Provenance & Evidence