HCID 17221241, compound → HCID 67010045, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(4-fluorophenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 218, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(4-fluorophenyl)piperazin-1-yl)acetamido)propanamide (13.3 mg, 27.7%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 8.01 (d, 1H), 7.60 (d, 2H), 7.26-7.30 (m, 5H), 7.19-7.25 (m, 2H), 6.98-7.01 (m, 6H), 6.92-6.95 (m, 2H), 4.70 (m, 1H), 4.52 (s, 2H), 3.72-3.80 (m, 2H), 3.07 (m, 6H), 2.59-2.65 (m, 4H). MS (EI) for C34H34F2N4O4. found 601.6 (MH+).

Provenance & Evidence