(2,6-Dimethylmorpholin-4-yl)acetic acid--hydrogen chloride (1/1) → HCID 67009462, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2,6-dimethylmorpholino)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 265, (2S)-3-(benzyloxy)-2-(2-(2,6-dimethylmorpholino)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (11.1 mg, 25.9%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.20 (s, 1H), 7.98 (d, 1H), 7.60 (d, 2H), 7.27-7.32 (m, 5H), 7.19-7.23 (m, 2H), 6.98-7.04 (m, 4H), 4.69-4.71 (m, 1H), 4.52 (s, 2H), 3.71-3.77 (m, 2H), 3.54-3.5 (m, 2H), 2.93-3.03 (m, 2H), 2.74 (dd, 2H), 1.73-1.80 (m, 2H), 1.00 (dd, 6H). MS (EI) for C30H34FN3O5. found 536.6 (MH+).

Provenance & Evidence