1158584-44-1 → HCID 67010434, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-thiomorpholinoacetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 266, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-thiomorpholinoacetamido)propanamide (14.2 g, 33.9%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 7.96 (d, 1H), 7.60 (d, 2H), 7.28-7.34 (m, 5H), 7.19-7.23 (m, 2H), 6.98-7.04 (m, 4H), 4.68-4.69 (m, 1H), 4.52 (s, 2H), 3.70-3.77 (m, 2H), 3.01 (s, 2H), 2.67-2.73 (m, 4H), 2.60-2.63 (m, 4H). MS (EI) for C28H30FN3O4S. found 524.6 (MH+).

Provenance & Evidence