反应详情

Proceeding as in Example 1, but substituting 2-(2,3-dioxa-8-azaspiro[4.5]decan-8-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 219, (2S)-2-(2-(2,3-dioxa-8-azaspiro[4.5]decan-8-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (21.7 mg, 48.1%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 8.00 (d, 1H), 7.60 (d, 2H), 7.27-7.33 (m, 5H), 7.20-7.23 (m, 2H), 6.98-7.04 (m, 4H), 4.68-4.70 (m, 1H), 4.52 (s, 2H), 3.88 (s, 4H), 3.69-3.79 (m, 2H), 3.00 (s, 2H), 2.51-2.54 (m, 4H), 2.63-2.65 (m, 4H). MS (EI) for C31H34FN3O6. found 564.6 (MH+).