2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, hydrochloride → HCID 67010117, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(3,4-dihydroisoquinolin-2(1H)-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 221, (S)-3-(benzyloxy)-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (15.6 mg, 35.2%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.20 (s, 1H), 8.03 (d, 1H), 7.60 (d, 2H), 7.22-7.26 (m, 5H), 7.19-7.21 (m, 2H), 7.12-7.15 (m, 3H), 6.98-7.04 (m, 5H), 4.73 (m, 1H), 4.50 (s, 2H), 3.71-3.79 (m, 2H), 3.70 (s, 2H), 3.18 (s, 2H), 2.83-2.86 (m, 2H), 2.71-2.81 (m, 2H). MS (EI) for C33H32FN3O4: 554.6 (MH+).

Provenance & Evidence