Azepan-1-ylacetic acid hydrochloride → HCID 45377860, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(azepan-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 128, (S)-2-(2-(azepan-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (21.7 mg, 52.2%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): 10.22 (s, 1H), 7.99 (d, 1H), 7.60 (d, 2H), 7.27-7.33 (m, 5H), 7.19-7.23 (m, 2H), 6.99-7.04 (m, 4H), 4.70 (m, 1H), 4.52 (s, 2H), 3.67-3.79 (m, 2H), 3.10 (m, 2H), 2.51-2.63 (m, 4H), 1.55-1.60 (m, 8 h). MS (EI) for C30H34FN3O4. found 520.6 (MH+).

Provenance & Evidence