(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009421, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(furan-2-carbonyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 223, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)propanamide (17 mg, 35.4%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): 10.22 (s, 1H), 8.04 (d, 1H), 7.84 (s, 1H), 7.61 (d, 2H), 7.26-7.31 (m, 5H), 7.19-7.23 (m, 2H), 6.98-7.04 (m, 5H), 6.63 (dd, 1H), 4.71 (m, 1H), 4.53 (s, 2H), 3.73-3.77 (m, 2H), 3.65 (s, 2H), 3.06 (m, 2H), 2.51-2.54 (m, 4H). MS (EI) for C33H33FN4O6. found 601.6 (MH+).

Provenance & Evidence