(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67010399, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(2-fluorophenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 127, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-fluorophenyl)piperazin-1-yl)acetamido)propanamide (13.1 mg, 27.3%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): 10.23 (s, 1H), 8.02 (d, 1H), 7.60 (d, 2H), 7.25-7.30 (m, 5H), 7.19-7.23 (m, 2H), 7.10-7.19 (m, 2H), 6.98-7.04 (m, 6H), 4.71 (m, 1H), 4.53 (s, 2H), 3.72-3.80 (m, 2H), 3.07 (d, 2H), 3.00 (m, 4H), 2.63 (m, 4H). MS (EI) for C34H34F2N4O4. found 601.6 (MH+).

Provenance & Evidence