HCID 17221245, compound → HCID 45376365, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(4-methoxyphenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 224, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(4-methoxyphenyl)piperazin-1-yl)acetamido)propanamide (17.2 g, 35.1%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 8.00 (d, 1H), 7.60 (d, 2H), 7.30-7.65 (m, 5H), 7.19-7.25 (m, 2H), 6.98-7.04 (m, 4H), 6.87-6.90 (d, 2H), 6.81-6.84 (d, 2H), 4.71 (m, 1H), 4.52 (s, 2H), 3.70-3.80 (m, 2H), 3.69 (s, 3H), 3.06 (s, 2H), 3.02 (m, 4H), 2.59-2.67 (m, 4H). MS (EI) for C35H37FN4O5. found 613.6 (MH+).

Provenance & Evidence