(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 178521317, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2-(1H-imidazol-4-yl)ethylamino)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 216, (S)-2-(2-(2-(1H-imidazol-4-yl)ethylamino)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (11.2 mg, 26.3%). 1H-NMR (400 MHz, DMSO-D6): σ 10.24 (s, 1H), 8.25 (d, 1H), 7.61 (d, 2H), 7.51 (s, 1H), 7.28 (m, 6H), 7.19 (t, 2H), 7.02 (m, 4H), 6.78 (s, 1H), 4.70 (m, 1H), 4.52 (s, 2H), 3.68 (m, 3H), 3.20 (s, 2H), 2.75 (m, 2H), 2.64 (m, 2H). MS (EI) for C29H30FN5O4: 532.6 (MH+).

Provenance & Evidence