(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67010230, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(4-acetylphenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 229, (S)-2-(2-(4-(4-acetylphenyl)piperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (10.2 mg, 20.4%). 1H-NMR (400 MHz, DMSO-D6): σ 10.23 (s, 1H), 8.04 (d, 1H), 7.81 (d, 2H), 7.60 (d, 2H), 7.23 (m, 7H), 7.01 (m, 6H), 4.71 (m, 1H), 4.52 (s, 2H), 3.74 (m, 1H), 3.33 (m, 5H), 3.07 (s, 2H), 2.61 (m, 4H), 2.46 (s, 3H). MS (EI) for C36H37FN4O5: 625.6 (MH+).

Provenance & Evidence