(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 45376498, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-acetylpiperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 230, (S)-2-(2-(4-acetylpiperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (13.4 mg, 31.3%). 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 8.03 (d, 1H), 7.99 (s, 1H), 7.61 (d, 2H), 7.30 (m, 5H), 7.21 (t, 2H), 7.00 (m, 4H), 4.70 (m, 1H), 4.52 (s, 2H), 3.73 (m, 2H), 3.34 (m, 4H), 3.06 (s, 2H), 2.41 (m, 4H). MS (EI) for C29H31FN4O5: 535.4 (MH+).

Provenance & Evidence