(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009727, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(octahydroquinolin-1(2H)-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 45, (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(octahydroquinolin-1(2H)-yl)acetamido)propanamide (20.1 mg, 44.9%). 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 7.84 (m, 1H), 7.59 (d, 2H), 7.28 (m, 7H), 7.02 (m, 4H), 4.69 (m, 1H), 4.51 (m, 2H), 3.73 (m, 2H), 3.34 (m, 2H), 3.33 (m, 2H), 2.97 (m, 1H), 2.75 (m, 1H), 2.17 (m, 1H), 1.42 (m, 11H). MS (EI) for C33H38FN3O4: 560.5 (MH+).

Provenance & Evidence