(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009827, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2-methylpyrrolidin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 63, (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-methylpyrrolidin-1-yl)acetamido)propanamide (19 mg, 47%). 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 7.93 (t, 1H), 7.60 (d, 2H), 7.29 (m, 5H), 7.19 (m, 2H), 7.00 (m, 4H), 4.73 (s, 1H), 4.52 (s, 2H), 3.69 (m, 2H), 3.05 (m, 1H), 2.82 (m, 1H), 2.46 (m, 1H), 2.23 (m, 1H), 1.91 (m, 1H), 1.67 (m, 2H), 1.33 (m, 1H), 1.03 (d, 3H). MS (EI) for C29H32FN3O4: 506.5 (MH+).

Provenance & Evidence