(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009279, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(3-methoxyphenyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 42, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(3-methoxyphenyl)piperazin-1-yl)acetamido)propanamide (15.7 mg, 32%). 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 8.01 (d, 1H), 7.60 (d, 2H), 7.26 (m, 7H), 7.11 (t, 1H), 7.01 (m, 4H), 6.50 (d, 1H), 6.43 (s, 1H), 6.37 (d, 1H), 4.70 (m, 1H), 4.52 (s, 2H), 3.77 (m, 1H), 3.73 (m, 4H), 3.13 (m, 4H), 3.06 (s, 2H), 2.61 (m, 4H). MS (EI) for C35H37FN4O5: 613.7 (MH+).

Provenance & Evidence